17^th Drug Discovery Innovation
Programme

Domainex is an award-winning integrated drug discovery research service partner, providing the full range of pre-clinical drug discovery services. They work collaboratively in partnership with clients from a variety of sectors including academic, pharmaceutical, biotechnology and patient foundation organisations around the world. their team comprises of approximately 70 scientists, who are committed to providing high quality services, and have expertise in:

• Protein production and characterisation
• X-ray crystallography
• Assay development and screening (biochemical, biophysical and cell assays)
• Computational chemistry including virtual screening
• Medicinal, synthetic and analytical chemistry
• Fragment- and structure-based drug discovery

Domainex has also established innovative technology platforms enabling us to offer unique services including:

Combinatorial Domain Hunting: our patented technology to quickly identify soluble, highly expressed domain constructs of proteins by combining semi-random gene fragmentation with efficient screening of the resulting protein fragments.

The first step towards a molecule becoming a drug is to be accepted as a clinical candidate. Before that, series of compounds are tested to ensure that the right molecule is chosen. ADME-Tox research is a crucial part of this path and that’s why leading pharma/biotech ompanies have made them part of their team. Admescope offers a broad portfolio of tailor-made ADME-Tox assays. Admescope’s expertise lies in drug metabolism, in vitro and in vivo metabolite profiling & identification, drug–drug interactions, early pharmacokinetics, and quantitative bioanalysis. In addition to small molecules and peptides, Admescope provides services for biologics. From small-molecule hit generation and lead optimization, through to complex route development and clinical supply, Symeres is ready to help create new therapies for unmet needs in the pharmaceutical and veterinary industries. Together with Symeres, they aim to have real, positive impact on people’s lives. they make molecules matter. Together.

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